Vanessa Carlysle is the love interest of Wade Wilson/Deadpool in Deadpool.
Wade Wilson is a former special forces operative who works as a mercenary in New York City.
He meets escort Vanessa Carlysle at a local bar and they become romantically attached.
One year later, Wade proposes to her and she accepts, but he suddenly collapses and Wade is diagnosed with terminal cancer and though Vanessa remains by his side, he fears losing her.
A recruiter from a secret program approaches Wade and offers him an experimental cure for his cancer. Although Wade initially refuses, he later decides to leave Vanessa and undergo the procedure.
At a laboratory, Wade meets Ajax and Angel Dust, whom he instantly resents. Ajax injects Wade with a serum designed to awaken latent mutant genes, then have him subjected to weeks of torture to trigger the mutation without success.
Wade discovers Ajax's real name, Francis Freeman, and makes fun of him. In response, Ajax straps Wade into an airtight chamber which raises and lowers the oxygen level to keep Wade constantly on the verge of asphyxiation.
Ajax reveals to Wade their true purpose: to make super-powered slaves to be sold to wealthy customers. Several days later, Wade develops a healing factor which cures his cancer, but severely disfigures his face and skin.
He escapes from the chamber and attacks Ajax, but relents when told that his disfigurement can be cured. Ajax subdues Wade, impales him with a rebar and leaves him in the burning laboratory.
Wade attempts to reconnect with Vanessa, but is unable to come to terms with his appearance, and keeps himself away from her. After consulting his best friend Weasel, Wade decides to hunt down Ajax and have his disfigurement cured.
He becomes a masked vigilante, takes the alias "Deadpool", and moves into the home of an elderly blind woman named Al, played by actress Leslie Uggams.
Following a string of leads, Deadpool tracks down Ajax to a convoy of cars on an expressway. He kills all the escorts, corners Ajax and demands a cure to his disfigurement.
The confrontation is interrupted by two X-Men, Colossus and Negasonic Teenage Warhead, who have been trying to recruit Deadpool.
Taking advantage of the distraction, Ajax escapes. Colossus handcuffs himself to Deadpool and begins dragging him away. Deadpool cuts off his own hand and escapes. His hand regenerates overnight.
Now knowing Wade is alive, Ajax goes to Weasel's bar and learns of Vanessa. Weasel calls Wade and tells him Vanessa is in danger.
Wade goes to the bar she works at but, unable to face her, psyches himself up in the bathroom first. However, when he comes out, she is already kidnapped.
Ajax and Angel Dust tell Deadpool to meet up with them on a decommissioned helicarrier in a scrapyard.
Deadpool convinces Colossus and Negasonic to help him, and the trio take a cab to the scrapyard. While Colossus and Negasonic battle Angel Dust, Deadpool fights his way through Ajax's henchmen, and eventually engages him in close combat.
After Angel Dust knocks out Colossus, Negasonic uses her power to repel her, but accidentally destroys the equipment holding the helicarrier upright.
As the helicarrier tips over, Colossus wakes up and takes Negasonic and Angel Dust to safety while Deadpool successfully saves Vanessa.
Ajax, still alive, attacks Deadpool, but is subdued and reveals there is no cure for Wade's disfigurement.
Colossus begins urging Deadpool to be a true hero and spare his enemy, but Deadpool kills Ajax. Wade turns to Vanessa, who removes his mask revealing his face.
Vanessa is angered that Wade left her, but still loves him. She accepts him, and they reconcile by kissing.
| Marvel Love Interests